Acetylcysteine

Author: Prof. Dr. med. Peter Altmeyer

Last updated on: 30.09.2022

Definition
This section has been translated automatically.

Mucolytic, expectorant, antioxidant.

6,25 h

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Dermatology

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Expectoration promotion in acute and chronic bronchopulmonary diseases. In high doses, ACC can be used as an antidote for paracetamol poisoning.

Pregnancy, lactation, bronchial asthma, encephalopathy, neonates and children < 12 months.

Promotion of expectoration: 3 times 200 mg/day p.o. or once/day 600 mg or 1-2 times/day 300 mg by inhalation or 1-2 times/day 300 mg slowly i.v. or i.m.; children receive half the dose!
Paracetamol poisoning: Start within 16 hours after intoxication: Initial 150 mg/kg bw in 200 ml 5% glucose solution i.v. for 15 minutes, then 50 mg/kg bw in 500 ml 5% glucose with electrolyte addition for 4 hours and 100 mg/kg bw in 1000 ml 5% glucose with electrolyte addition for 16 hours.

See table.

See table.

Hypersensitivity to the active substance.

ACC, Bisolvon, Bromuc, Fluimucil, Siran, Stas

It is important to ensure a sufficient supply of liquid, as this is the basis of the expectoration-promoting effect!

Airways	bronchospasm, dyspnoea, rhinitis Hemoptysis
Blood, lymph	anaemia, thrombocyte aggregation inhibition
GIT	Nausea, vomiting, diarrhoea
Urinary tract	Immunocomplex nephritis
Skin	allergic reactions (pruritus, exanthema, urticaria, Stevens-Johnson syndrome, angioedema) Stomatitis drug-induced lupus erythematosus
Cardiovascular	facial edema, hypotension, anaphylactic shock
Nervous System	Headaches
Sense Organs	Tinnitus

Ampicillin	Ampicillin effect ↓, Ampicillin intake delayed for 2 hours
Antitussives	Secretory congestion, avoid combination
Carindacillin	Carindacillin effect ↓, Carindacillin 2 hours delayed intake
Cefaclor	Cefaclor effect ↓, Cefaclor 2 hours delayed intake
Cefadroxil	Cefadroxil effect ↓, Cefadroxil 2 hours delayed intake
Cefalexin	Cefalexin-Wikung ↓, Cefalexin 2 hours delayed intake
Cefixim	Cefixim effect ↓, Cefixim 2 hours delayed intake
Cefradine	Cefradin effect ↓, Cefradin intake delayed for 2 hours
Codeine	Secretory congestion, avoid combination
Epicillin	Epicillin effect ↓, Epicillin 2 hours delayed intake
Glycerol trinitrate	vasodilatory and antiplatelet aggregation effect ↑
Hydrocodone	Secretory congestion, avoid combination