Androgens

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Synthetically produced male sex hormones.

Indication
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Substitution therapy for testosterone deficiency due to hypogonadism. see also mesterolone, testosterone nantate, testosterone propionate, testosterone undecanoate.

Limited indication
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Lactation (masculinization of the infant), boys before puberty, age > 65 years, epilepsy, severe cardiac, hepatic or renal insufficiency, liver tumors, migraine, acute intermittent porphyria, prostate hypertrophy.

Undesirable effects
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Allergic reactions including anaphylaxis, depression, increased or decreased libido, headache, intracerebral bleeding, edema, blood clotting disorders (decrease in factors II, V, VII and X), water retention, hypercholesterolemia, polycythemia, acute intermittent porphyria, pubertas praecox in boys, penis enlargement, frequent erections, etc.Irreversible virilization, liver dysfunction, amenorrhea, testicular atrophy, impotence, hypertrophy of the clitoris, hypertrophy of the prostate, premature closure of the epiphysis, acne, alopecia, hirsutism, seborrhea, irreversible deepening of the voice in women.

Interactions
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Taking Ajmalin at the same time leads to a long lasting cholestasis, coumarins lead to an increased bleeding tendency.

Contraindication
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Pregnancy (masculinization of female fetuses), singers, prostate carcinoma, tumor-related hypercalcemia.

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Last updated on: 29.10.2020