Atovaquone/proguanil

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 20.05.2022

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Definition
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Active ingredient combination for malaria therapy from Atovaquon and Proguanil.

Spectrum of action
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Effective against blood and hepatic schizons of P. falciparum (Malaria tropica).

Indication
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Prophylaxis of malaria tropica and treatment of acute, uncomplicated malaria tropica, especially if P. falciparum may be resistant to other antimalarial drugs.

Pregnancy/nursing period
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Strict indication (insufficient data available).

Dosage and method of use
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Malarone (250 mg atovaquone/100 mg proguanil per tbl.):

  • Adults, children > 40 kg bw: 4 film bl. as ED on 3 consecutive days.
  • Children: 11-20 kg bw: 1 tbl./day each for 3 consecutive days; 21-30 kg bw: 2 tbl. each as ED for 3 consecutive days; 31-40 kg bw: 3 tbl. each as ED for 3 consecutive days.

Prophylaxis: 1 tablet p.o. 1 time/day 1-2 days before entering endemic area, continue during stay and 7 days after leaving endemic area.

Reminder. If vomiting occurs as a side effect after taking the medication, the dose should be taken again (especially for malaria prophylaxis)!

Undesirable effects
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Occasional headache, abdominal pain, diarrhea, fever, nausea, vomiting, pruritus.

Interactions
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Reduction of atovaquone plasma levels with simultaneous treatment with metoclopramide, tetracyline, rifampicin, rifabutin.

Contraindication
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Malaria prophylaxis in patients with severely impaired kidney function (creatinine clearance < 30 ml/min).

Preparations
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Malarone, Malarone Junior

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Last updated on: 20.05.2022