Hydroxyethyl starch

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

HAES

Definition
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Plasma expanders made of amylopectin with molecular weights between 40,000 and 450,000 Daltons. HAES is given for volume substitution and hemodilution.

Undesirable effects
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Dermatologically, a severe itching observed after HAES infusion, in 20-60% of patients, due to storage of the smallest HAES particles in macrophages is of significance. It can occur 1-6 weeks after the start of infusion therapy and persists for 12-24 months. S.u. pruritus after HAES infusions.

Note(s)
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Ultrastructural detection of HAES particles using immunoelectron microscopy. Clinic and Polyclinic for Skin Diseases, Westfälische Wilhelms-University Münster.

Literature
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  1. Bork K (2005) Pruritus precipitated by hydroxyethyl starch: a review. Br J Dermatol 152: 3-12

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Last updated on: 29.10.2020