Toxic oil syndrome T65.3

Author: Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

Dieser Artikel auf Deutsch

Synonym(s)

TOS; toxic oil syndrome

Definition
This section has been translated automatically.

Disease caused by poisoned edible oil with a phase-like course and great clinical similarity to chronic autoimmune diseases of the vascular connective tissue.

Occurrence/Epidemiology
This section has been translated automatically.

Epidemic 1981 in Spain.

Etiopathogenesis
This section has been translated automatically.

Consumption of rapeseed oil denatured with aniline.

Manifestation
This section has been translated automatically.

  • Acute phase: Women and men are equally affected.
  • Chronic phase: Women are affected 6 to 10 times more frequently than men.

Clinical features
This section has been translated automatically.

  • Acute phase: 7-10 days after consumption fever, dyspnoea due to interstitial pneumonia and pulmonary oedema, gastrointestinal problems.
  • Subacute phase: After about 2 months, non-specific pruriginous skin changes, maculopapular or urticarial erythema, arthralgia, myalgia.
  • Chronic phase: From the 4th month, in 10-15% of patients neuromuscular syndrome with scleroderma-like or poikilodermatic skin symptoms. Livedo reticularis, Raynaud's syndrome, Sjögren's syndrome, carpal tunnel syndrome, dysphagia or pulmonary hypertension may also occur.

Laboratory
This section has been translated automatically.

Eosinophilia. IgE elevation. ANA positive 35-80% of the time.

Differential diagnosis
This section has been translated automatically.

Therapy
This section has been translated automatically.

Progression/forecast
This section has been translated automatically.

Chronic stage: Progression over years. In the acute stage death by pulmonary complications.

Literature
This section has been translated automatically.

  1. Bell S et al (1992) The toxic oil syndrome - an example of an exogenously induced autoimmune disease. dermatologist 43: 339-343
  2. Sanchez-Porro Valades P et al (2003) Toxic oil syndrome: survival in the whole cohort between 1981 and 1995 J Clin Epidemiol 56: 701-708
  3. Hubbard V et al (2003) Scleromyxoedema-like changes in four renal dialysis patients. Br J Dermatol 148: 563-568

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

Authors

Last updated on: 29.10.2020