Breast adenoma D24.x3

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Adenoma of the nipple papillary; Adenoma of the nipple papillary proliferating; Adenomatosis of the nipple; Adenomatosis of the nipple erosive; Cystadenoma papillary intraductal; Erosive adenomatosis of the nipple; florid subareolar papillomatosis; intra-ductal benign papilloma; Milk duct adenoma; papillary adenoma of the nipple; papillary intraductal cystadenoma; Papilloma intraductales benignes; Papillomatosis floride subareolar; proliferating papillary adenoma of the nipple

History
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Collins, 1905; Warren, 1905

Definition
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Manifestation
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Mostly occurring in women in the 5th decade of life.

Clinical features
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Reddish to erosive, scaly, crusty plaque (pseudopagetoid!) in the nipple area with enlargement, bleeding, weeping and pain (see below thelalgia) of the nipple.

Histology
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In continuity with the epidermis, proliferation of cystic and tubular structures with cylindrical epithelium. Detection of papillary projections into the lumen. External myoepithelial cells.

Differential diagnosis
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Paget's disease of the nipple; intraductal papillary carcinoma of the milk duct.

Therapy
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Local excision of the tumor, whereby the absence of tumor should be observed by means of microscopically controlled surgery.

Progression/forecast
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No malignant degeneration.

Literature
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  1. Albers SE et al (1999) Erosive adenomatosis of the nipple in an eight-year-old girl. J Am Acad Dermatol 40: 34-837
  2. Bourlond J et al (1992) Erosive Adenomatosis of the nipple. Dermatology 185: 319-324
  3. Cooper A (1845) The anatomy and diseases of the breast. Lea & Blanchard, Philadelphia, S. 1-130
  4. Healy CE et al (2003) Nipple adenoma: a differential diagnosis for Paget's disease. Breast J 9: 325-326
  5. Lee HJ, Chung KY (2002) Erosive adenomatosis of the nipple: Conservation of nipple by Mohs micrographic surgery. J Am Acad Dermatol 47: 578-580
  6. Sugai M et al (2002) Adenoma of the nipple in an adolescent. Breast Cancer 9: 254-256
  7. Undeutsch W et al. (1979) Papillomatous lactiferous adenoma (pseudo paget of the nipple). Dermatologist 30: 371-375
  8. Van Mierlo PL et al (1998) Mohs micrographic surgery for an erosive adenomatosis of the nipple. Dermatol Surgery 24: 681-683
  9. Warren JC (1905) The surgeon and the pathologist: a plea for reciprocity as illustrated by the consideration of the classification and treatment of benign tumors of the breast. JAMA 45: 149-165

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Last updated on: 29.10.2020