Cyproterone acetate

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 13.09.2021

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Definition
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Half-life
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48 ± 10 h

Indication
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Medium to severe acne, seborrhea, alopecia androgenetica (see alopecia androgenetica in women, alopecia androgenetica in men), hirsutism in women.

Limited indication
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6 weeks before planned operations, long-term immobilization (e.g. after accidents), smokers > 30 years, liver diseases (e.g. porphyria), renal failure, heart failure, Z.n. thrombophlebitis, Raynaud's disease, peripheral circulatory disorders, edema.

Dosage and method of use
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Initially 100 mg/day p.o. from 1st to 10th day of cycle in combination with antiandrogen-estrogen combination preparation (e.g. Diane 35), after clinical improvement 50 mg/day from 1st to 10th day of cycle in combination with Diane 35 or Diane 35 alone.

Notice! In case of absence of menstruation exclude pregnancy before taking again!

Undesirable effects
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Anemia, weight gain, gynecomastia, galactorrhea, menstrual disorders, libido loss, cholestasis, liver dysfunction, angioedema, thrombosis, fatigue, depression, muscle weakness, osteoporosis.

Interactions
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The blood sugar-lowering effect of insulin, metformin and sulfonylureas is reduced.

Contraindication
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Pregnancy, lactation, liver diseases, Z.n. pemphigoid gestationis, liver tumours, consuming diseases (except Prostata-Ca), tendency to thrombosis, sickle cell anaemia, severe diabetes mellitus, severe chronic depression, adolescents before the end of puberty.

Preparations
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Androcur®, Virilit®

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Last updated on: 13.09.2021