Keratinamyloidoses - Altmeyers Encyclopedia

Definition
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Non-systemic, localized amyloidoses which occur exclusively in the skin and are characterized by deposition of amyloid (amylum = starch) of epidermal origin.

Classification
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A distinction is made between:

Etiopathogenesis
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Probably in apoptotic keratinocytes the alpha-helix structure of the keratins is transformed into a ß-leaf structure. These proteins cannot be cleared by macrophages and remain in the papillary dermis as keratinamyloid (detected by antibodies against keratin filaments). This explains the "high" dermal position of the amyloid deposits in the skin.