DefinitionThis section has been translated automatically.
Antibiotic from the active substance class of oxazolidinones. In addition, the substance is considered a reversible, non-selective MAO inhibitor without antidepressant effect at doses similar to those used in antibiotic therapy.
Spectrum of actionThis section has been translated automatically.
- Bacteriostatically effective against Gram-positive aerobes such as enterococci, staphylococci (incl. MRSA), streptococci and Gram-positive anaerobes such as clostridia and peptostreptococci. Not effective against gram negative pathogens!
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Notice! Low cross-resistance with other antibiotic classes, also effective against pathogens with resistance to penicillin, oxacillin and vancomycin!
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IndicationThis section has been translated automatically.
Severe skin or soft tissue infections caused by gram-positive pathogens, nosocomial and ambulantly acquired pneumonia.
Pregnancy/nursing periodThis section has been translated automatically.
Insufficient data on use during pregnancy or breastfeeding (in case of therapy: weaning!).
Dosage and method of useThis section has been translated automatically.
Pat. > 18 y.: 2 times/day 600 mg p.o./i.v.
Note ! Regular, weekly blood count checks during therapy!
Undesirable effectsThis section has been translated automatically.
Frequent: headache, mycosis (especially vulvovaginal candidiasis), gastrointestinal symptoms with taste disorders, diarrhoea, nausea, vomiting, transient liver dysfunction.
PreparationsThis section has been translated automatically.
Zyvoxide
Note(s)This section has been translated automatically.
- Fully bioavailable after oral administration
- Good tissue penetration
- Liquor flow
- Good tolerance
- No cross-resistance to other antibiotics.
LiteratureThis section has been translated automatically.
- Ntziora F et al (2007) Linezolid for the treatment of patients with central nervous system infection. Ann Pharmacother 41: 296-308
Prof. Dr. med. Peter Altmeyer