Melanoacanthoma D23.L

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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History
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Bloch, 1927; Mishima and Pinkus, 1960

Definition
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Mixed tumor in which melanocytes and keratinocytes proliferate evenly; variant of the pigmented acanthotic Verruca seborrhoica.

Manifestation
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In adults, usually occurring after the 40th LJ.

Clinical features
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Deeply pigmented, slow-growing, wart-like tumour which is indistinguishable from Verruca seborrhoica.

Histology
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Proliferation of basaloid epithelial cells, melanocytes distributed over all layers of the tumor and numerous melanophages in the dermis.

Differential diagnosis
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Therapy
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Melanoacanthoma is usually a histological diagnosis by chance. Since it was removed in toto either under the suspected diagnosis "malignant melanoma" or "pigmented verruca seborrhoica", further surgical measures of this benign tumor are not necessary. If necessary, the residual tumor can be cured in LA.

Progression/forecast
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Benign.

Literature
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  1. Bloch B (1927) On benign, non-naevoidal melanoepitheliomas of the skin together with remarks on the nature and genesis of dendrite cells Arch Dermatol Syph (Berlin) 153: 20-40
  2. Mishima Y, Pinkus H (1960) Benign mixed tumor of melanocytes and malpighian cells. Arch Dermatol 81: 539-550
  3. Fornatora ML et al (2003) Oral melanoacanthoma: a report of 10 cases, review of the literature, and immunohistochemical analysis for HMB-45 reactivity. At J Dermatopathol 25: 12-15
  4. Vion B et al (1989) Melanoacanthoma of the penis shaft. Report of a case. Dermatologica 179: 87-89

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Last updated on: 29.10.2020