Type-2-transmembranprotein

Last updated on: 02.09.2021

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Definition
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Transmembrane proteins form an important class of membrane proteins that permeate the entire phospholipid bilayer of a cell. They account for almost one third of the total protein content of cells and are of great importance for the functionality of the cell and the cell organelles.

A distinction is made between singlepass transmembrane proteins, which cross the membrane only once, and multipass transmembrane proteins, which cross the membrane several times.

The singlepass transmembrane proteins are called type-1 transmembrane proteins if the N-terminus is located extracellularly.

The singlepass transmembrane proteins are called type-2 transmembrane proteins when the N-terminus is intracellular.

Last updated on: 02.09.2021

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