Results for "Psoriasis"

...s inflammatory processes and is used to treat flare-ups in adult patients with generalized pustular psoriasis. In the pivotal EFFISAYIL® 1 study, there was a numerical advantage of spesolimab for the GPPASI 75...

...n in the pathogenesis of autoimmune diseases. A Th-17 accentuated inflammatory pattern dominates in psoriasis and rheumatoid arthritis. This particular inflammatory pattern is responsible for the infiltration...

...mice are susceptible. Note(s) Janus kinase (JAK) inhibitors have demonstrated clinical efficacy in psoriasis in both phase 2 and phase 3 trials and appear to be well tolerated overall (Kvist-Hansen A et al. 2...

...thomechanisms. Representative AiKDs are the different variants of generalized or localized pustular psoriasis. For this heterogeneous group of diseases, mutations/variants in five genes - IL36RN, CARD14, AP1S3...

Calcipotriol Definition Vitamin D3 analogue. Indication Mild to moderate psoriasis vulgaris of the plaque type with an extension of < 30% of the body surface. Dosage and method of...

...ds specifically to chemokine receptor 10 (CCR10). The CCR10 receptor is expressed by lymphocytes in psoriasis. Studies on a similar mouse protein suggest that these protein-receptor interactions may play a cen...

...d, if necessary, the entire integument should be examined (e.g. in atopic diseases and in suspected psoriasis). If the vulva is to be assessed in more detail, vulvoscopy is recommended, which allows examinatio...

...ns have also been described in M.Darier, pityriasis rubra pilaris, mycosis fungoides, erythrodermic psoriasis, M. Grover . Some cases have been observed during treatment with vemurafenib and other biologics. O...

...lizumab. JDDG 9: 834Farewell M et al (2003) A novel target T-cell modulator, Efalizumab, for plaque psoriasis. N Engl J Med 349: 2004-2013Merckserono (2009) Important announcement. Drug safety. germany @mercks...

...nostics are recommended for the initial diagnosis.If the clinical picture indicates the presence of psoriasis, histological confirmation of the diagnosis should be sought, as this is essential for long-term th...

...Henoch purpura (Mani LY et al. 2015). Complicatively, IgA nephropathy (IgAN) may be associated with psoriasis (often severe) (Garces CC et al. 2021). Laboratory Non-selective proteinuria (usually <3g/day) a...

...NF-α and thus prevent the release of IL-1 and IL-6. They are used to treat chronic diseases such as psoriasis vulgaris, psoriasis arthropathica, rheumatoid arthritis, Crohn's disease. Cytokine antibody (usteki...

...complexed with IL-20R2. Occurrence It has been shown that IL-22 is involved in the pathogenesis of psoriasis. For example, IL-22 can inhibit the differentiation of keratinocytes and induced psoriasis-like cha...

...pidermis.Thus, deletion of two members, LCE3B and LCE3C (LCE3B/C-del) has been shown to be a common psoriasis risk factor that interacts with the major psoriasis risk gene HLA-C*06. LCE3A is directly adjacent...

...lls and CD8+ cytotoxic cells. It has broad significance in inflammatory pathogenetic pathways (e.g. psoriasis, the systemic scleroderma). In psoriasis, LL-37 is upregulated. In wound healing, the antimicrobial...

...ymmetric (zoster; nevus flammeus, cutaneous mosaics; other skin infections)preferentially extensor (psoriasis vulgaris)preferentially flexural (atopic eczema, lichen (ruber) planus)arranged in the Blaschko lin...

...emotherapy. S.u. PUVA-therapy and KUVA-therapy. Indication Among other things for the treatment of: Psoriasis parapsoriasis en plaques Pruritus prurigo simplex subacuta Mycosis fungoides (erythema and plaque s...

...inhibitors and steroids. However, this could not be confirmed in a subsequent study. In the case of psoriasis inversa, clinical improvements after topical application of Pimecrolimus ( off-label-use) (see calc...

Nail pitting due to psoriasis Definition Superficial, fine, barely 0.1 cm large, round or oval, punctate depressions of the nail...

...ing skin disease of unexplained etiology and pathogenesis, which was classified in the group of parapsoriasis diseases, i.e. psoriasis-like diseases, by the work of Brocq (1902). (Note: this classification can...

...ARCAL1 geneImmunodeficiency 10 and NFKB2 defect (vitiligo, autoimmune thyroiditis, endocrinopathies)Psoriasis and psoriasiform exanthemaIL10 defects/mutation in IL10RA/IL10RBICF syndrome/mutation in DNMT38/ ZB...

...8.Lis-Święty A et al. (2022) Proactive therapy: new perspectives for long-term topical treatment of psoriasis. Dermatol Ther. ;35: e15364Lavaud J et al (2020) Proactive treatment in childhood psoriasis. Ann De...

...otein family. It was first identified as an 11.4 kDa cytoplasmic and secreted protein isolated from psoriasis-affected skin that can be induced in cultured squamous cells.It was later revealed to be expressed...

PSORS3 Definition PSORS3 (PSORS3 stands for: Psoriasis Susceptibility 3) is a genetic locus on chromosome 4q associated with psoriasis. Seven susceptibili...

...ints and the upper rib cartilages, which is frequently accompanied by pustulosis palmo-plantaris or psoriasis pustulosa palmo-plantaris. Most likely an abortive manifestation form of psoriatic arthritis.Rare a...