Azulen

Authors: Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

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Last updated on: 29.10.2020

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Synonym(s)

Cyclopentacycloheptene

Definition
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Azulene (from span.azul "blue") Group of blue to violet (hence the name) aromatic hydrocarbons, which as an essential oil was obtained as early as the 15th century during the steam distillation of chamomile. Azulene is practically insoluble in water, but dissolves in organic solvents. Azulenes are formed from colourless precursors, the proazulenes. Azulenes can also be obtained synthetically from sesquiterpenes (see terpenes below ).

Spectrum of action
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topical: antiphlogistic, antiseptic; in cultures UV-protective

Field of application/use
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Azulene is found in many essential oils:

  • Chamazulene (roman chamomile, yarrow, wormwood)
  • Guajazulen (Eucalyptus globulus, Geranium)

Standard concentration
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0.2% in water-absorbing ointments (absorption bases), hydrophilic ointments, hydrophobic creams (W/O emulsion ointments), hydrophilic creams (O/W emulsion ointments), hydrophilic gels (hydrogels) Apply 1-2 times/day to the affected areas

Preparations
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Ophthalmo Azulen eye ointment (available from international pharmacies), Emser Nasal Ointment without menthol

Literature
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  1. Ueki J et al.(2013) Anti-UV activity of newly-synthesized water-soluble azulenes. In Vivo 27:119-126.

Incoming links (1)

Oleum chamomillae;

Outgoing links (2)

Chamomile real; Terpenes;