Oat syndrome - Altmeyers Encyclopedia - Department Dermatology

Synonym(s)

Oligo-Astheno-Teratozoospermia Syndrome

Definition
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Idiopathic disorder of spermatogenesis with reduced sperm count (less than 20 million/ml), reduced motility (less than 50% 4 hours after ejaculation), morphological malformation rate over 50%. In most cases, fertility is considerably restricted.

Therapy
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No causal therapy. The following therapeutic approaches can be attempted if you wish to have children:

Anti-oestrogens: By blocking hypothalamic oestrogen receptors, reflective release of FSH/ LH, leads to increased activity of the Leydig intermediate cells and thus to an improvement in sperm count, their motility and morphology. Tamoxifen (e.g. Nolvadex) 30 mg/day p.o. for 3 months (10-40 mg/day) is used.
Gonadotropins: For hypo- or normogonadotropic hypogonadism, combined HMG/HCG therapy. HCG (Human Chorionic Gonadotropin) (e.g. Predalon) 1000-2000 IU 1 time per week i.m. or s.c. in combination with HMG (Human Menopausal Gonadotropin) (e.g. Menogon) 3 times per week 150 IU i.m. over several months.
Androgenic glucocorticoids: Effective in oligozoospermia with teratozoospermia, e.g. mesterolone (e.g. Proviron-25 Tbl.) 2-3 times 25 mg/day for 3-6 months.
In vitro fertilization: In vitro fertilization can be attempted in the presence of mature, motile sperm.