DefinitionThis section has been translated automatically.
Cytostatic, antiestrogen.
See also under "Targeted tumour therapeutics"(aromatase inhibitors).
Half-lifeThis section has been translated automatically.
168–240 h
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IndicationThis section has been translated automatically.
Breast cancer in the postmenopause. Metastatic malignant melanoma ( off-label use).
Dosage and method of useThis section has been translated automatically.
20-40 mg/day p.o.
Undesirable effectsThis section has been translated automatically.
Edema, vaginal bleeding, thrombo- and leucopenia, depression, allergic skin reactions, headaches, hot flashes, hyperhidrosis. Rarely blood count, liver or kidney disorders. The risk of endometrial carcinoma is 5 times higher.
So-called radiation recall dermatitis has been described, initiated by previous exposure to radiation or UV light.
ContraindicationThis section has been translated automatically.
Women of childbearing age.
PreparationsThis section has been translated automatically.
Nolvadex®, Tamoxifen-ratiopharm®
Prof. Dr. med. Peter Altmeyer